Activation of L-type Ca channels by protein kinase C is reduced in smooth muscle-specific Na /Ca exchanger knockout mice
نویسندگان
چکیده
Chongyu Ren, Jin Zhang, Kenneth D. Philipson, Michael I. Kotlikoff, Mordecai P. Blaustein, and Donald R. Matteson Departments of Physiology and Medicine, University of Maryland School of Medicine, Baltimore, Maryland; Department of Physiology, University of California Los Angeles School of Medicine, Los Angeles, California; and Department of Biomedical Sciences, Cornell University Veterinary College, Ithaca, New York
منابع مشابه
Activation of L-type Ca2+ channels by protein kinase C is reduced in smooth muscle-specific Na+/Ca2+ exchanger knockout mice.
L-type voltage-gated Ca(2+) channels (LVGCs) are functionally downregulated in arterial smooth muscle (SM) cells (ASMCs) of mice with SM-specific knockout of Na(+)/Ca(2+) exchanger type-1 (NCX1(SM-/-)) (32). Here, using activators and inhibitors of protein kinase C (PKC), we explore the regulation of these channels by a PKC-dependent mechanism. In both wild-type (WT) and NCX1(SM-/-) myocytes, t...
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cardiomyocytes from wild-type and GRK2 knockout (GRK2KO) mice without (sham) or with myocardial infarction (MI). In cardiac myocytes isolated from unstressed wild-type and GRK2KO hearts, myocyte contractions and Ca transients were similar, but GRK2KO myocytes had lower sarcoplasmic reticulum (SR) Ca content because of increased sodium-Ca exchanger activity and inhibited SR Ca ATPase by local pr...
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